Immunotherapy for colorectal cancer
作者： David Tougeron , Émilie Fauquembergue , Jean-Baptiste Latouche
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摘要: Recent studies have underlined the close link between immune response and prognosis of patients with colorectal cancer (CRC). Immune understanding combined biotechnology progress last years has allowed development immunotherapy strategies in CRC. Immunotherapy are divided "active" or "passive" (patients system stimulation not) considering activation antigen specific not. These well tolerated induced cellular humoral correlated clinical response. Many monoclonal antibodies targeting signalisation pathways angiogenic growth factors demonstrated their efficacy Multiple vaccine strategies, using different tumour associated antigens, a biological but poor results. Results more promising adjuvant setting need to be confirmed by randomized trials. Adoptive transfer T cell is probably most strategy. Actually, except antibodies, not used practice CRC due lack results absence standardisation.
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