Organ-cultured, prestripped donor tissue for DMEK surgery: clinical outcomes

摘要: Aim To determine whether clinical performance is negatively affected by prestripping Descemet membrane endothelial keratoplasty (DMEK) grafts from organ-cultured corneas. Methods We reviewed records of all patients who underwent DMEK surgery for Fuchs dystrophy between 28 October 2014 and 11 August 2015. Grafts had been prepared corneoscleral buttons 24 hours prior to or during surgery. included only which at least one follow-up examination was available a minimum 2 months postoperatively. Main outcome measures: best-corrected visual acuity (BCVA), central corneal thickness, cell count rebubbling rates. Results Data given are mean±SD. No statistically significant differences were recorded baseline the partially stripped group (n=65) control (n=72) with regard donor age (70±9 vs 69±8 years; p=0.49), cornea density (2586±604 2522±186 cells/mm 2 ; p=0.6), BCVA (before DMEK: 0.77±0.5 0.63±0.3 logMAR; p=0.27; before triple-DMEK: 0.56±0.2 0.52±0.2 p=0.33) thickness (621±72 607±53 μm; p=0.49). Mean 149±83 versus 148±77 days; p=0.79. observed two groups postoperatively (after 0.25±0.2 0.21±0.2 p=0.59; after 0.22±0.2 0.2±0.1 p=0.98), (502±42 508±41 μm; p=0.47), (1537±245 1551±287 cells/mm p=0.65) number graft detachments requiring (4.6% 9.7%; p=0.33). Conclusions found no evidence that use prestripped inferior same-day preparation in corneas within follow-up.