Intensively timed induction therapy followed by autologous or allogeneic bone marrow transplantation for children with acute myeloid leukemia or myelodysplastic syndrome: a Childrens Cancer Group pilot study.
作者： W G Woods , N Kobrinsky , J Buckley , S Neudorf , J Sanders
DOI: 10.1200/JCO.1993.11.8.1448
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摘要: PURPOSEChildrens Cancer Group (CCG) protocol 2861 was designed to test the feasibility of aggressively timed induction therapy followed by autologous or allogeneic bone marrow transplantation (BMT) as sole postremission for newly diagnosed children with acute myeloid leukemia (AML) myelodysplastic syndrome (MDS).PATIENTS AND METHODSBetween April 1988 and October 1989, 142 patients were eligible study. All entered received a timing-intensive five-drug dexamethasone, cytarabine (Ara-C), thioguanine, etoposide, daunorubicin (DCTER) over 4 days second cycle administered after 6 rest, irrespective hematologic status at that time. Most subsequently two-cycle course. Those who achieved remission ablative busulfan cyclophosphamide, 4-hydroperoxy-cyclophosphamide (4-HC)-purged BMT rescue.RESULTSOne hundred eight (76%) achiev...
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