Genetic aspects of the etiology of arrhythmia

摘要: Cardiac arrhythmias are common causes of morbidity and mortality in clinical medicine. Much has been learned about cellular mechanisms arrhythmogenesis the past but genetic components have only recently recognized for some heritable forms arrhythmias. The long QT syndrome Brugada both caused by molecular defects ion channel proteins. can also be associated with structural heart diseases. For example, sinus node dysfunction or AV-block precede inherited dilated cardiomyopathy. A distinct form hypertrophic cardiomyopathy is Wolff-Parkinson-White maps to chromosome 7q35. Arrhythmogenic right ventricular a strong basis often manifests tachycardia. Atrial fibrillation occur as familial disease may allelic diseases closely linked 10q2.