Aboriginal and non-Aboriginal children in Western Australia carry different serotypes of pneumococci with different antimicrobial susceptibility profiles

摘要: Carriage of Streptococcus pneumoniae is considered a precursor to pneumococcal diseases including pneumonia. As part the Kalgoorlie Otitis Media Research Project, we characterised pneumococci isolated from nasopharynx Western Australian Aboriginal and non-Aboriginal children. Between 1999 2005, 100 180 children were followed birth two years, with nasopharyngeal aspirates collected at ages 1–3 6–8 weeks, then 4, 6, 12, 18 24 months. Introduction 7-valent conjugate vaccine (7vPCV) in 2001 enabled evaluation its impact on carriage study participants according vaccines doses received. Pneumococcal serotyping was performed by Quellung antimicrobial susceptibility disk diffusion Etest®. Molecular epidemiology isolates investigated pulse-field gel electrophoresis multilocus sequence typing. Overall, prevalence 7vPCV serotypes similar for (19 % vs. 16 %), but non-vaccine higher (22 % 7 %). A multi-resistant 6B clone (ST90) found only who received three had lower odds carrying (odds ratio [OR] 0.19, 95 % CI 0.08–0.44) (OR 2.37, 1.13–4.99) than unvaccinated children; this finding not observed This unique shows important differences serotypes, genotypes, between living same geographic area before widespread use, highlights need ongoing post-vaccination surveillance outback Australia.