Taxane-Induced Peripheral Neurotoxicity.

摘要: Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel most commonly administered, but newer formulations being investigated. Taxane antineoplastic activity is mainly based on the ability of to promote microtubule assembly, leading mitotic arrest apoptosis cells. Peripheral neurotoxicity major non-hematological adverse effect taxane, often manifested as painful neuropathy experienced during treatment, it sometimes irreversible. Unfortunately, taxane-induced an uncertainty prior initiation The present review aims dissect current knowledge real incidence, underlying pathophysiology, clinical features predisposing factors related with development neuropathy.