The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation.
作者： Virginia L. Pimmett , Hua Deng , Julie A. Haskins , Rebecca J. Mercier , Paul LaPointe
DOI: 10.1016/J.YDBIO.2017.03.013
关键词:
摘要: The Drosophila vestigial gene is required for proliferation and differentiation of the adult wing larval muscle identity. Vestigial part a multi-protein transcription factor complex, which includes Scalloped, TEAD-class DNA binding protein. Binding Scalloped necessary translocation into nucleus. We show that extensively post-translationally modified at least one these modifications proper function during development. have shown there p38-dependent phosphorylation Serine 215 in carboxyl-terminal region Vestigial. Phosphorylation occurs nucleus requires presence Scalloped. Comparison phosphomimetic non-phosphorylatable mutant forms shows differences ability to rescue phenotypes associated with null allele.
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