Disulfide Bond Mimetics: Strategies and Challenges

摘要: The activity profile of many biologically relevant proteins and peptides often relies on a precise 3D structural organization. In this context, disulfide bonds are natural covalent constraints that play key role in driving stabilizing the folding pattern these molecules. Despite its prominent significance as motif, bond itself is inherently unstable under physiological conditions, posing major limit to use development disulfide-rich molecular tools drug lead compounds. To tackle restriction, engineering with stable functional analogues has arisen considerable interest. Here, most popular approaches replacement reviewed discussed particular emphasis advantages limitations both synthetic perspectives.