Effects of separate and combined chronic mercuric chloride and sodium selenate administration in rats: histological, ultrastructural, and x-ray microanalytical studies of liver and kidney.

摘要: The separate administration of mercuric chloride (HgCl/sub 2/) and sodium selenate (Na/sub 2/SeO/sub 4/) to male rats in drinking water or a combined both caused different signs toxicity over 22 week period. HgCl/sub 2/ group showed histopathological ultrastructural lesions as evidenced by periportal fatty degeneration cell necrosis the liver tubular with proteinaceous casts kidney. Na/sub 4/ most severe depression growth food consumption, but no pathological changes were seen Simultaneous toxicants produced protective effect on weight loss histopathology. basis interaction these two elements appears result from an alteration chemical form association mercury selenium.