Microwave synthesis of core-shell structured biocompatible magnetic nanohybrids in aqueous medium

摘要: In the past decade, biocompatible magnetic nanohybrids, i.e. materials consisting of an inorganic core encapsulated by a polymeric corona, went throw various developments in biomedical applications especially fields diagnosis and therapy. Numerous descriptions their syntheses can be found literature (Zhang et al., 2002; Flesch 2004; Fan 2007; etc). These two-steps protocols often describe use organic or aqueous solvents, classical thermal heating, long time reaction as well fastidious exchange drying steps. recent years, microwave heating has been proven to very original technology for nanoparticles synthesis due its almost instantaneous “in core” homogeneous selective way. As consequence, this allows interesting control over crystallization rate size nanomaterials (Bellon 2001; Michel The formation is usually realized medium. However, functionalization mainly conducted solvent. For further applications, it seems favorable realize these different grafting steps maintaining initial medium, thus avoiding solvent exchanges particles drying. context, we summarize objective chapter study new methods obtain core-shell structured nanohybrids medium from iron oxide water-soluble polymers. Is possible colloidal suspension well-defined with simplified relatively short time? This divided three part, first one, general presentation (properties, synthesis). second part deals principles description microwave-assisted nanoparticles. Finally, last dedicated towards nanohybrid compared process focus on characterization (morphology, grafted amount polymer).