Low bone mineral density predicts incident heart failure in men and women: the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk prospective study.

摘要: Abstract Objectives It is unknown whether bone mineral density as a measure of osteoporosis associated with development heart failure. Background Recent evidence suggests shared risk factors between failure and osteoporosis. Additionally, patients are at increased for cardiovascular disease. Methods We examined the prospective association measured broadband ultrasound attenuation by quantitative heel incident events in 13,666 apparently healthy persons 42 to 82 years age participating EPIC (European Prospective Investigation into Cancer Nutrition) study Norfolk, United Kingdom. Results During mean follow-up 9.3 years, 380 cases occurred. The decreased increasing density. hazard ratios comparing each quartile lowest were 0.40 (95% confidence intervals [CI]: 0.27 0.59), 0.54 CI: 0.37 0.79), 0.46 0.32 0.68) analysis adjusting age, sex, smoking, alcohol consumption, physical activity, occupational social class, educational level, systolic blood pressure, diabetes, cholesterol concentration, body mass index (p trend = 0.002), 23% decrease every increase 1 standard deviation (hazard ratio [HR]: 0.77; 95% 0.66 0.89). was stronger without (HR: 0.75; 0.63 0.89) than antecedent myocardial infarction 0.82; 0.62 1.09). Conclusions observed an inverse in apparently individuals. Our findings give support cardiac assessment people reduced bone mineral density warrant further exploration underlying biological mechanisms linking heart failure.