The role of the neutrophil and free radicals in ischemic myocardial injury

摘要: The association of coronary artery thrombosis with the onset acute myocardial infarction has provided rationale for development pharmacologic and/or physical methods restoration blood flow. institution reperfusion resulted in a reduction mortality leading to acceptance thrombolytic therapy as standard approach management patients an evolving [I]. It is well established fact that prolonged ischemia leads time-dependent loss viability cells jeopardized region heart and flow fundamental order arrest progression cell death function. essential repair reversible changes induced by continued survival at risk permanent damage. reintroduction oxygen time reperfusion, however, may be detrimental reoxygenated myocyte being beneficial. A number recent reviews have been devoted examination question whether reactive species or radicals can contribute irreversible injury during period [2, 3, 4, 51. purpose this editorial focus attention on potential role polymorphonuclear leukocyte (PMN) determinant ultimate extent after call those factors which modulate inflammatory response injury.