Enterolactone is differently associated with estrogen receptor beta-negative and -positive breast cancer in a Swedish nested case-control study

摘要: Background: Differences in the estrogen receptor (ER) status of tumors may explain ambiguities epidemiologic studies between blood concentrations enterolactone and breast cancer. To our knowledge, association ERβ-defined cancer has previously not been examined. Methods: A nested case-control study within Malmo Diet Cancer cohort used 366 cases 733 matched controls to identify major determinants plasma examine concentration risk if this differs depending on ERα ERβ tumors. modified diet history method assessed dietary habits. Time-resolved fluoroimmunoassay determined immunohistochemistry using tissue microarray ER status. Results: Dietary fiber, as well fruits berries, high-fiber bread showed statistically significant correlations with ( r , 0.13-0.22). Smoking obesity were associated lower concentrations. Enterolactone above median (16 nmol/L) reduced when compared those below [odds ratio, 0.75; 95% confidence interval (95% CI), 0.58-0.98]. The was only observed for [positive (+); odds 0.73; CI, 0.55-0.97] [negative (−)] (odds 0.60; 0.42-0.84), significantly different risks (−) (+) P heterogeneity = 0.04). Conclusions: This supports suggestion that is a biomarker healthy lifestyle. protective most evident express but ERβ. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3241–51)