Brain 5-HT1C receptors and antidepressants.

摘要: Abstract 1. A variety of antidepressants different chemical classes were tested for their in vivo and vitro activity at 5-HT1C receptors the brain. 2. Conventional tricyclic (imipramine, desipramine, maprotiline, clomipramine, trimipramine, amitriptyline, nortriptyline, doxepin, amoxapine, oxaprotiline) two atypical (mianserin trazodone) found to display affinity nanomolar range. 3. Antidepressants other mechanisms action (serotonin uptake inhibitors: fluoxetine, citalopram, sertraline, fluvoxamine; noradrenaline dopamine nomifensine, bupropion, amineptine; or monoamine oxidase moclobemide, iproniazid) had affinities micromolar range receptors, except fluoxetine. 4. When an functional model revealing agonistic antagonistic properties all displaying high this receptor type (except trimipramine antagonists receptors. with lower nomifensine) inactive model. 5. Antagonism brain is a component antiserotonergic number established antidepressants, especially class.