Investigação experimental da utilidade da medicação no pós-operatório em cirurgia refrativa

摘要: PURPOSE: To harvest microorganisms from the microkeratome after LASIK. induce experimental infectious keratitis and investigate use of routine postoperative medication. METHODS: During eight consecutive days, we cultured plate Dilutions most frequent microorganism was prepared according to MacFarland scale. Ten microliters were injected into both corneas guinea pigs. The right cornea used as control left treated with 0.3% ciprofloxacin associated dexamethasone ketorolac tromethamine every 4 hours for 24 (group 2). animals sacrificed divided two halves, which sent analyzed by microbiology histopathology laboratory. RESULTS: In group, Staphylococcus aureus could be retrieved all corneas, while in group 2, only 50% showed positive cultures (p=0.0128). Histopathology concerning polymorphonuclear cells an intense degree inflammation 1 (p=0.0203) regarding monomorphonuclear cells, it also more (p=0.0051). CONCLUSION: This study suggests that wide-spectrum antibiotic anti-inflammatory eye drops has a significant effect on reduction potential inflammatory process refractive surgery.