Stress increases metastatic spread of a mammary tumor in rats: Evidence for mediation by the immune system

作者: Shamgar Ben-Eliyahu , R Yirmiya , JC Liebeskind , AN Taylor , RP Gale

DOI: 10.1016/0889-1591(91)90016-4

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摘要: Causal relationships among stress, immune suppression, and enhanced tumor development have often been suggested, but direct evidence is scant. We studied stress effects in Fischer 344 rats using a model which lung metastases of syngeneic mammary (MADB106) are controlled by natural killer (NK) cells. Animals exposed to acute showed substantial decrease NK cell cytotoxicity against this an vitro assay and, when intravenously injected with tumor, twofold increase surface metastases. The critical period during increases appears be the same as that known These findings support hypothesis can facilitate metastatic process via suppression system.

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