Nitrotyrosine attenuates the hemodynamic effects of adrenoceptor agonists in vivo: relevance to the pathophysiology of peroxynitrite.
作者： Neil W. Kooy , Stephen J. Lewis
DOI: 10.1016/0014-2999(96)00376-7
关键词:
摘要: Peroxynitrite, which attenuates catecholamine-mediated hemodynamic responses in vivo, nitrates free tyrosine residues to form the specific product, 3-nitro-L-tyrosine. The chemical structure of 3-nitro-L-tyrosine is similar that endogenous catecholamines. Therefore, may interfere with catecholamine function vivo. produced by norepinephrine (1-4 micrograms/kg, i.v., n = 6), epinephrine (0.5-4 7), phenylephrine (1-8 5), and isoproterenol (100-400 ng/kg, 5) were attenuated, while arginine vasopressin (50-250 ng/kg; unaffected following administration (2.5 mumol/kg, i.v.) pentobarbital-anesthetized rats. These results demonstrate substantial selective attenuation effects alpha- beta-adrenoceptor agonists, raising possibility play a role dysfunction associated inflammatory conditions formation peroxynitrite favored.
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