Merkel Cell Carcinoma: Chemotherapy and Emerging New Therapeutic Options

摘要: Merkel cell carcinoma (MCC) is a rare neuroendocrine skin tumor that typically occurs in elderly, immunosuppressed patients. Infection with virus (MCV) and immunosuppression play an important role the development of MCC. Different staging systems make it difficult to compare existing clinical data. Furthermore, there predominantly exist single case reports series, but no randomized controlled trials. However, necessary develop further therapy options because MCC tends grow rapidly metastasizes early. In metastatic disease, therapeutic attempts were made various chemotherapeutic combination regimens. Because high toxicity these combinations, especially those established SCLC, regarding unsatisfying results, challenge balance pros cons chemotherapy individually carefully. Up now, emerging new as molecular-targeted agents, for example, pazopanib, imatinib, or somatostatin analogues well immunologicals, imiquimod interferons, also showed less success concerning disease-free response rates. According literature, neither nor agents immunotherapeutic strategies have shown promising effects disease so far. There great demand studies need registry multicenter trials due tumors curiosity.