Phospholipase A2 regulation of arachidonic acid mobilization
作者： Jesús Balsinde , Michelle V Winstead , Edward A Dennis
DOI: 10.1016/S0014-5793(02)03413-0
关键词:
摘要: Phospholipase A2 (PLA2) constitutes a growing superfamily of lipolytic enzymes, and to date, at least 19 distinct enzymes have been found in mammals. This class has attracted considerable interest as pharmacological target view its role lipid signaling involvement variety inflammatory conditions. PLA2s hydrolyze the sn-2 ester bond cellular phospholipids, producing free fatty acid lysophospholipid, both which are molecules. The produced is frequently arachidonic (AA, 5,8,11,14-eicosatetraenoic acid), precursor eicosanoid family potent mediators that includes prostaglandins, thromboxanes, leukotrienes lipoxins. Multiple PLA2 active within surrounding cell these distinct, but interconnected roles AA release.
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