Dose-Response Relationships for Female Radium Dial Workers

摘要: Among 1474 women employed in the United States radium dial-painting industry before 1930, there are 61 known cases of bone sarcoma and 21 carcinoma paranasal sinuses or mastoid air cells (''head carcinomas''). The relative effectiveness /sup 226/Ra 228/Ra dose-incidence relationships were examined for 759 these whose body burden has been determined; 38 17 head this group. Incidence (I) was expressed as tumor per person-year dose parameter (D) quantity (microcuries) that entered blood during period exposure. To observed data each type fitted equations can be formulated from general form I = (C + alpha dD+ ..beta..D/sup 2/)e-..gamma../sup D/, where C, natural incidence population, about 10-/sup 5/ person-year. For equation, best values coefficients found by a least-squares fitting procedure. An equation BD/sup 2/)e-/sup ..gamma..D/ provided fit sarcomas, when microcuries plusmore » 2.5 times 228/Ra. acceptable to linear C d ..gamma.. with D equal 226/Ra. As test bias due selection symptoms malignancy, analyses repeated after removal all whom determined only exhumation, no significant changes found. obtained average skeletal rad also given.« less