Regulation and metabolic engineering strategies for permeases of Saccharomyces cerevisiae

作者: Peng Zhang , Qian Chen , Guiming Fu , linglin Xia , Xing Hu

DOI: 10.1007/S11274-019-2684-Z

关键词:

摘要: Microorganisms have evolved permeases to incorporate various essential nutrients and exclude harmful products, which assists in adaptation different environmental conditions for survival. As are directly involved the utilization of regulatory response nutrient sources, metabolic engineering microbial can predictably influence metabolism regulation. In this mini-review, we summarized mechanisms underlying general regulation permeases, current advancements future prospects strategies targeting Saccharomyces cerevisiae. The types their been discussed. Furthermore, methods highlighted. Understanding via meticulously regulated engineered will not only facilitate research on global nutrition yeast engineering, but also provide important insights studies synthesis valuable products elimination substances S.

参考文章(140)
Eckhard Boles, Bruno André, Role of transporter-like sensors in glucose and amino acid signalling in yeast Molecular Mechanisms Controlling Transmembrane Transport. ,vol. 9, pp. 155- 178 ,(2004) , 10.1007/B95773
Johan M. Thevelein, Ken Peeters, Glucose Sensing and Signal Transduction in Saccharomyces cerevisiae Springer Berlin Heidelberg. pp. 21- 56 ,(2014) , 10.1007/978-3-642-55013-3_2
Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel, Abdullah Yalcin, Klaus Weber, Thomas Tuschl, Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature. ,vol. 411, pp. 494- 498 ,(2001) , 10.1038/35078107
J F Tschopp, S D Emr, C Field, R Schekman, GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae. Journal of Bacteriology. ,vol. 166, pp. 313- 318 ,(1986) , 10.1128/JB.166.1.313-318.1986
A L Kruckeberg, L F Bisson, The HXT2 gene of Saccharomyces cerevisiae is required for high-affinity glucose transport. Molecular and Cellular Biology. ,vol. 10, pp. 5903- 5913 ,(1990) , 10.1128/MCB.10.11.5903
M J Charron, R A Dubin, C A Michels, Structural and functional analysis of the MAL1 locus of Saccharomyces cerevisiae. Molecular and Cellular Biology. ,vol. 6, pp. 3891- 3899 ,(1986) , 10.1128/MCB.6.11.3891
D A Lewis, L F Bisson, The HXT1 gene product of Saccharomyces cerevisiae is a new member of the family of hexose transporters. Molecular and Cellular Biology. ,vol. 11, pp. 3804- 3813 ,(1991) , 10.1128/MCB.11.7.3804
Meng Wang, Chenzhao Yu, Huimin Zhao, Directed evolution of xylose specific transporters to facilitate glucose-xylose co-utilization Biotechnology and Bioengineering. ,vol. 113, pp. 484- 491 ,(2016) , 10.1002/BIT.25724
A Nourani, M Wesolowski-Louvel, T Delaveau, C Jacq, A Delahodde, Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters. Molecular and Cellular Biology. ,vol. 17, pp. 5453- 5460 ,(1997) , 10.1128/MCB.17.9.5453