Metabolic Regulation of Insulin Secretion

摘要: Abstract Regulation of metabolic fuel homeostasis is a critical function β-cells, which are located in the islets Langerhans animal pancreas. Impairment this β-cell hallmark pancreatic failure and may lead to development type 2 diabetes mellitus. β-Cells essentially “fuel sensors” that monitor react elevated nutrient load by releasing insulin. This response involves activation generation coupling factors (MCFs) relay signal throughout cell induce insulin biosynthesis secretion. Glucose most important secretagogue as it primary source food. metabolism central MCFs release, notably ATP. In addition, other classes nutrients able augment secretion these include members lipid amino acid family nutrients. Therefore, investigate interplay between glucose, lipid, metabolism, mixed sensing generate required for exocytosis. The mechanisms metabolized MCFs, how they impact on release function, discussed detail article.