Highly regioselective C4-hydrazinylation of 2,4-dichloroquinolines: expedient synthesis of aminoquinoline substituted pyrrolidin-2,5-diones via hydrazinylquinolines
作者： Gopal Senthil Kumar , Matthias Zeller , Rajesh Ghanshyam Gonnade , Karnam Jayarampillai Rajendra Prasad
DOI: 10.1016/J.TETLET.2014.05.132
关键词:
摘要: A new class of hydrazinylquinoline regio-isomers has been synthesized through SNAr reaction 2,4dichloroquinolines with hydrazine hydrate. The stops at the mono-substitution product high regioselectivity C4 rather than C2 position dichloroquinolines. hydrazinylquinolines were subsequently converted into aminoquinoline substituted pyrrolidin-2,5-diones in presence Eaton’s reagent.
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