METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS: EXPERIENCE IN A GENERAL HOSPITAL OVER FOUR YEARS

摘要: From 1977 to 1981, 317 patients in a large general hospital became infected with methicillin- and gentamicin-resistant Staphylococcus aureus. The epidemic strain was characterized as bacteriophage type D11/83A/85, resistant methicillin, cephalosporins aminoglycosides, contained 24 megadalton plasmid which mediated gentamicin resistance. Spread within the followed introduction of this organism into surgical burn services resulted from cross infection between patients. These remained reservoir throughout four-year period. Only 2% personnel carried methicillin-resistant S. aureus their anterior nares, only one them shown be long-term carrier. During epidemic, there no overall increase serious staphylococcal infections, reflected bacteremias. As increased, reciprocal decrease methicillin-sensitive Later, bacteremias decreased, increased. Attempts control spread by containing on an isolation ward, or placing all such strict isolation, decreased frequency but did not eliminate organism. In 1980, service separated moved new unit. Also, five-bed rooms were being converted two-bed rooms. With routine precautions, resolved over next year, although persists hospital.