Selection on the FADS region in Europeans
作者： Matthew T Buckley , Fernando Racimo , Morten E Allentoft , Majken K Jensen , Anna Jonsson
DOI: 10.1101/086439
关键词:
摘要: FADS genes encode fatty acid desaturases that are important for the conversion of short chain polyunsaturated acids (PUFAs) to long acids. Prior studies indicate have been subjected strong positive selection in Africa, South Asia, Greenland, and Europe. By comparing sequencing data from present-day Bronze Age (5-3k years ago) Europeans, we identify possible targets European population, which suggest has targeted different alleles Europe than it Asia or Greenland. The showing strongest changes allele frequency since show associations with expression multiple lipid-related phenotypes. Furthermore, selected associated a decrease linoleic an increase arachidonic eicosapentaenoic among Europeans; this is opposite effect observed Inuit We SNPs region affect levels PUFA synthesis. Additionally, find evidence gene-environment interaction influencing low-density lipoprotein (LDL) between affecting synthesis dietary intake: carriers selected, derived diminished increases LDL cholesterol higher intake PUFAs. hypothesize selective patterns Europeans were driven by change composition following transition agriculture, resulting lower acid, but α-linolenic acid.
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