Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
作者： Tulio Guadalupe , Samuel R. Mathias , Theo G. M. vanErp , Christopher D. Whelan , Marcel P. Zwiers
DOI: 10.1007/S11682-016-9629-Z
关键词:
摘要: The two hemispheres of the human brain differ functionally and structurally. Despite over a century research, extent to which asymmetry is influenced by sex, handedness, age, genetic factors still controversial. Here we present largest ever analysis subcortical asymmetries, in harmonized multi-site study using meta-analysis methods. Volumetric seven structures was assessed 15,847 MRI scans from 52 datasets worldwide. There were sex differences globus pallidus putamen. Heritability estimates, derived 1170 subjects belonging 71 extended pedigrees, revealed that additive these hippocampus thalamus. Handedness had no detectable effect on even this unprecedented sample size, but putamen varied with age. Genetic drivers hippocampus, thalamus basal ganglia may affect variability cognition, including susceptibility psychiatric disorders.
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