Recombinant flagellin protein and preparation and use thereof

摘要: The present invention provides an optimized recombinant flagellin protein and preparation use thereof. is with a deletion in the hypervariable region, said region from 180 to 400 amino acid of protein, proteins include FliCΔ190-278, FliCΔ220-320 or FliCΔ180-400. method preparing comprising introducing into protein. First constructed plasmid, then used it as template construct cloning, expressed purified. also adjuvant. decreases potential risks may have, its antigenicity immunogenicity inflammatory response induced by it, through deleting main areas antigen activity.