Chapter 5.2: Five-Membered Ring Systems: Pyrroles and Benzo Analogs

摘要: Publisher Summary This chapter discusses pyrroles and benzo analogs. Pyrroles indoles are amongst the most studied heterocyclic ring systems because of their diverse biological activity materials science applications. Pyrrole rings important structural subunits recognition elements found in a number bioactive materials, including small molecule natural products tetrapyrroles (i.e., porphyrins) related macrocycles. The also recent implementation traditional methods development novel strategies for synthesis indole alkaloids. isolation characterization new alkaloids remains fruitful avenue discovery agents with potential biomedical application. Oxindoles spirocyclic variants represent general class that have received considerable attention as synthetic targets, well key intermediates product synthesis. Strategies core structures several been reported. In developing biomimetic approach toward haplophytine, Corey co-workers investigated direct coupling two partners form an aspidophytine mimic tetracyclic canthiphytine analog.