Principles of Cell Behavior on Titanium Surfaces and Their Application to Implanted Devices

摘要: The term “tissue engineering” has become a catchall phrase that generally describes the use of materials are specifically designed to restore, maintain or improve function human tissues or, as in case dental implants, replace them. may be combined with cells cultured outside body implanted directly. Tissue engineering is an interdisciplinary field theory should apply principles biology and solution thorny problems interfacing artificial devices living tissues. In fact however, while material well known, more subtle biological often unknown obscure. net result that, noted Dr. Buddy Ratner’s Presidential address American Biomaterials Society 1996, current biomaterials have been developed trial error optimization rather than specific design [1]. Yet achieve responses from difficult prospect if governing cell interaction implant not established understood. consequence part tissue equation taken precedence. For example, it was recognized mechanical retention implants might improved by incorporation macroscopic features such screw threads vents for bone ingrowth, micro using sandblasted plasma-sprayed surfaces. Many surfaces varying microscopic topography were some these successful [2], but their did proceed knowledge response