Systemic Treatment of Advanced Colorectal Cancer: Tailoring Therapy to the Tumor

摘要: Colorectal cancer is a prevalent disease in Western countries. While prevention through screening the best approach to combat development of colorectal removal precursor adenomas, many patients present with advanced that will require surgery and systemic therapy improve survival. With reference therapy, median survival metastatic (those tumor spread lymph nodes or distant sites) has improved over past three decades due introduction 5-fluorouracil (5-FU), its subsequent biomodulation, addition other chemotherapeutic agents. There now evidence biology tumor, stage cancer, may predict response 5-FU-based therapy. More recently, biological therapies target signaling processes for growth, such as epidermal growth factor receptor, vascular endothelial factor, are also effective improving patient cancer. The use combination include chemotherapy biologic should continue increase appropriately designed clinical trials. Treatments based on need be examined