Ileal resection-induced gallstones: altered bilirubin or cholesterol metabolism?

摘要: Ileal resection has been shown to increase the risk of cholelithiasis. Earlier studies in humans suggested that ileal increases cholesterol saturation index. Recent data from patients on long-term parenteral nutrition and animals, however, have predisposes pigment gallstone formation. We therefore tested hypothesis alters bile calcium bilirubin metabolism without affecting Adult male prairie dogs underwent either sham laparotomy (eight dogs) or (16 dogs). All animals were fed a trace (nonlithogenic) diet before for 4 weeks after operation. Pigment gallstones present 44% ileal-resected none (p less than 0.05). Calcium bilirubinate crystals 94% 0.01). Gallbladder (25.6 +/- 2.4 versus 17.2 1.1 mg/dl; p 0.05) total (29.3 4.0 9.4 1.8 0.01) concentrations significantly greater animals. The index gallbladder bile, was no different (0.53 0.04) sham-operated (0.50 0.04). Although initial hepatic increased resection, second set experiments demonstrated this phenomenon resulted washout salts already extremely low bile. conclude alterations bilirubin, but not cholesterol, result formation resection.