Decreased Brush Border Hydrolase Activities Without Gross Morphologic Changes in Human Intestinal Mucosa After Prolonged Total Parenteral Nutrition of Adults
作者： C. Guedon , J. Schmitz , E. Lerebours , J. Metayer , E. Audran
DOI: 10.1016/0016-5085(86)90935-2
关键词:
摘要: Animal experimentation with total parenteral nutrition (TPN) has revealed the occurrence of atrophy intestinal mucosa and decreased enzyme activities brush border, notably disaccharidases. These findings have heretofore not been confirmed in human investigation. We performed endoscopic biopsies third part duodenum 7 adults before TPN, after 21 days a progressive oral refeeding. noted clear-cut decrease major during TPN (sucrase, maltase, lactase, glucoamylase, acid aminopeptidase, dipeptidyl peptidase) without any morphologic modifications as observed standard histology. Electron microscopy showed slight but significant height microvilli. The were rapidly restored Thus, functional consequences medium-term are probably limited.
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