Inflammation-induced cholestasis
作者： Michael Trauner , Peter Fickert , Rudolf E Stauber
DOI: 10.1046/J.1440-1746.1999.01982.X
关键词:
摘要: Inflammatory cytokines produced in response to various infectious and non-infectious stimuli are potent inducers of intrahepatic cholestasis (inflammation-induced cholestasis). The cholestatic effect results mainly from inhibition expression function hepatocellular transport systems which normally mediate hepatic uptake biliary excretion bile salts non-bile salt organic anions (e.g. bilirubin). These cytokine effects reversible secretory is restored upon disappearance the inflammatory injury. This review summarizes clinical, pathophysiological molecular aspects inflammation-induced cholestasis.
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