The role of TET-mediated DNA hydroxymethylation in prostate cancer
作者： E. Smeets , A.G. Lynch , S. Prekovic , T. Van den Broeck , L. Moris
DOI: 10.1016/J.MCE.2017.08.021
关键词:
摘要: Abstract Ten-eleven translocation (TET) proteins are recently characterized dioxygenases that regulate demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine and further derivatives. The recent finding 5hmC is also a stable independent epigenetic modification indicates these play an important role in diverse physiological pathological processes such as neural tumor development. Both the genomic distribution of (hydroxy)methylation expression activity TET dysregulated wide range cancers including prostate cancer. Up now it still unknown how changes 5(h)mC profiles related pathogenesis In this review, we explore advances current understanding function regulated development Furthermore, look at impact on cancer potential underlying mechanisms. Finally, tried summarize latest techniques for detecting quantifying global locus-specific levels DNA.
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