Investigating maspin in breast cancer progression using mouse models.
作者： Michael P. Endsley , Ming Zhang
DOI: 10.1016/B978-0-12-386471-0.00008-0
关键词:
摘要: Clade B serpin family of proteins regulate a variety cellular functions including cell adhesion and motility. One key member the clade is maspin (SERPINB5). Maspin classified as type II tumor suppressor that regulates invasion. It expressed in normal mammary epithelial cells but reduced benign breast tumors absent invasive carcinomas. Although apoptosis, adhesion, migration, invasion cancer culture systems, mouse models are necessary to verify this vivo. In chapter, we review development transgenic syngeneic study role tumorigenesis development.
sci-hub.se 参考文章(49)
F. Kittrell, H. Y. Shi, D. Medina, R. Liang, Ming Zhang, N. S. Templeton, Weiguo Zhang, Modeling human breast cancer metastasis in mice: maspin as a paradigm. Histology and Histopathology. ,vol. 18, pp. 201- 206 ,(2003) , 10.14670/HH-18.201
J.A. Mietz, T. Unger, J.M. Huibregtse, P.M. Howley, The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. The EMBO Journal. ,vol. 11, pp. 5013- 5020 ,(1992) , 10.1002/J.1460-2075.1992.TB05608.X
Ming Zhang, Shijie Sheng, Nicolai Maass, Ruth Sager, MMASPIN : THE MOUSE HOMOLOG OF A HUMAN TUMOR SUPPRESSOR GENE INHIBITS MAMMARY TUMOR INVASION AND MOTILITY Molecular Medicine. ,vol. 3, pp. 49- 59 ,(1997) , 10.1007/BF03401667
J Potempa, E Korzus, J Travis, The serpin superfamily of proteinase inhibitors: structure, function, and regulation. Journal of Biological Chemistry. ,vol. 269, pp. 15957- 15960 ,(1994) , 10.1016/S0021-9258(17)33954-6
S Sheng, P A Pemberton, R Sager, Production, purification, and characterization of recombinant maspin proteins. Journal of Biological Chemistry. ,vol. 269, pp. 30988- 30993 ,(1994) , 10.1016/S0021-9258(18)47379-6
Frank McCormick, Cancer gene therapy: fringe or cutting edge? Nature Reviews Cancer. ,vol. 1, pp. 130- 141 ,(2001) , 10.1038/35101008
Frances S. Kittrell, Daniel Medina, Carol J. Oborn, Development of mammary preneoplasias in vivo from mouse mammary epithelial cell lines in vitro. Cancer Research. ,vol. 52, pp. 1924- 1932 ,(1992)
David A. Conner, Transgenic Mouse Production By Zygote Injection Current Protocols in Molecular Biology. ,vol. 68, ,(2004) , 10.1002/0471142727.MB2309S68
Howard A. Bern, Phyllis B. Blair, K. B. DeOme, L. J. Faulkin, Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Research. ,vol. 19, pp. 515- ,(1959)
Milena Gasco, Shukri Shami, Tim Crook, The p53 pathway in breast cancer Breast Cancer Research. ,vol. 4, pp. 70- 76 ,(2002) , 10.1186/BCR426