Predicting prostate carcinoma volume and stage at radical prostatectomy by assessing needle biopsy specimens for percent surface area and cores positive for carcinoma, perineural invasion, Gleason score, DNA ploidy and proliferation, and preoperative serum prostate specific antigen: a report of 454 cases.

摘要: BACKGROUND DNA ploidy analysis of prostate carcinoma is a generally accepted prognostic marker, particularly when tumors are extraprostatic at the time surgery. In past decade, DNA content frequently has been assessed in needle biopsy specimens based on assumption that ploidy, conjunction with serum specific antigen (PSA) and Gleason score, provides valuable pretreatment information. METHODS Between 1995 1998, authors identified consecutive series 454 carcinomas, verified by biopsies followed radical retropubic prostatectomies (RRP). Based biopsies, MIB-I immunostaining were measured digital image (DIA). The also quantified percent nuclei four categories from histograms. DIA data combined age patient diagnosis, PSA, cores surface area positive for carcinoma, status perineural invasion multivariate models using tumor volume risk extension (EPE) RRP as outcome variables. RESULTS Joint predictors (P < 0.0001), PSA classified quantification to be “S-phase” category = 0.03). Joint EPE 0.0004), score 7 8 or 9 0.006) 0.02). CONCLUSIONS After adjusting traditional markers, interpretation quantitation did not appear jointly predict either variable models. However, quantitative measure related both proliferation, putative histograms, was found volume. Cancer 2001;91:02196–204. © 2001 American Society.