ZNF366 is a novel corepressor for estrogen receptor alpha that mediates its effects through interaction with CtBP

摘要: Regulation of gene expression by the estrogen receptor (ER) requires coordinated recruitment and dissociation transcriptional coactivator complexes concomitant chromatin remodelling histone modification. In addition to well-characterised proteins, a number corepressor proteins can also be recruited liganded ER, including RIP140 L-CoR. We have recently identified new ER interacting protein, ZNF366, which is through interactions involving zinc finger domains both proteins. We show that repression ER-regulated genes ZNF366 involves well-described CtBP. This interaction mediated two sequence motifs in conforming consensus CtBP-binding motif (PXDLS). Mutation these reduces, but does not abolish, activity ZNF366. Additionally, interacts with RIP140, raising possibility may act synergistically regulating [1]. Finally, we although expressed normal breast epithelial cells, its detected cancer cells. raises regulation important development.