Cytotoxic Effects of Interferon in Vitro on Granulocytic Progenitor Cells

摘要: We have utilized in vitro marrow culture techniques to evaluate the cytotoxicity for granulocytic progenitor cells of two highly purified human leukocyte interferon preparations. Concentration- and time-related decrements colony-forming capacity agar occurred with mouse marrow. Although were less sensitive than cells, these data indicate lack strict species specificity cell growth-inhibitory effects interferon. Similar was noted normal leukemic clonogenic exposed prolonged periods. The decrease proportion DNA synthesis, which at high concentrations, diminution by caused cytosine arabinoside demonstrate that decreases synthesis cells. enhanced rapidly proliferating post-endotoxin indicates is not a cycle-stage-specific drug. These seem useful evaluating suppressive on granulopoiesis devising clinical trials this agent.