p8 attenuates the apoptosis induced by dihydroartemisinin in cancer cells through promoting autophagy
作者： Sang-Sang Chen , Wei Hu , Zeng Wang , Xiao-E Lou , Hui-Jun Zhou
DOI: 10.1080/15384047.2015.1026477
关键词:
摘要: Dihydroartemisinin (DHA) exhibits anticancer activities in a variety of cancer cells, but DHA alone are not effective enough for therapy. In this study we found the stress-regulated protein p8 was obviously increased after treatment several which further to induce autophagy by upregulation endoplasmic reticulum stress-related ATF4 and CHOP. Furthermore, when silenced siRNA apoptosis induced were notably increased, whereas overexpression cells leaded resistance DHA-induced apoptosis. Moreover, inhibition with chloroquine (CQ) can enhance effect both vitro vivo. conclusion, that p8-mediated attenuates provides evidence support use as therapeutic target, suggests combination inhibitor might be an strategy.
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