Prime-Boost Vaccination: Impact on the HIV-1 Vaccine Field
作者： Robert De Rose , Stephen J. Kent , Charani Ranasinghe
DOI: 10.1016/B978-0-12-416603-5.00012-2
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摘要: An HIV vaccine is urgently needed but likely to require vaccination strategies that induce broad, robust, and high-quality immune responses. Prime-boost for HIV-1 vaccines have been widely studied in both primate models humans. The first partially successful humans utilized a recombinant canarypox virus expressing antigens as priming envelope protein booster vaccine, induced high-level antibody responses correlated with 31% protection from infection. Several other prime-boost approaches also robust CD8 T-cell immunity HIV-1, thus there growing hope combination can broader longer-lived systemic mucosal will yield an improved efficacy. This chapter reviews aimed at preventing
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