MicroRNA Expression Profile in Peripheral Blood Lymphocytes of Sheep Vaccinated with Nigeria 75/1 Peste Des Petits Ruminants Virus.
作者： Yang Yang , Xiaodong Qin , Xuelian Meng , Xueliang Zhu , Xiangle Zhang
DOI: 10.3390/V11111025
关键词:
摘要: Peste des petits ruminants (PPR) is one of the highly contagious transboundary viral diseases small ruminants. Host microRNA (miRNA) expression patterns may change in response to virus infection, and it mainly works as a post-transcriptional moderator gene affects pathogenesis replication. In this study, miRNA profile peripheral blood lymphocyte (PBMC) from sheep inoculated with PPR vaccine vivo well primary testicular (ST) cells vitro were determined via deep sequencing technology. PBMC cells, 373 115 differentially expressed miRNAs (DEmiRNAs) identified 3 days 5 post (dpi), respectively. While, 575 DEmiRNAs when comparing profiles on dpi dpi. Some found significantly time-course during inoculated. Similarly, ST 136 at comparison mock-inoculation. A total 12 validated by real-time quantitative PCR (RT-qPCR). The oar-miR-150, oar-miR-370-3p oar-miR-411b-3p common both virus-inoculated cells. Targets prediction functional analysis uncovered gathering antigen processing presentation pathways, protein endoplasmic reticulum pathways cell adhesion molecules pathways. Our study supplies information about provides clues for further understanding function
mdpi.com
sci-hub.se 参考文章(83)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Pankaj Trivedi, Eleni Anastasiadou, Neha Garg, Rachele Bigi, Shivangi Yadav, Antonio Francesco Campese, Caterina Lapenta, Massimo Spada, Laura Cuomo, Annalisa Botta, Filippo Belardelli, Luigi Frati, Elisabetta Ferretti, Alberto Faggioni, Epstein‐Barr virus infection induces miR‐21 in terminally differentiated malignant B cells International Journal of Cancer. ,vol. 137, pp. 1491- 1497 ,(2015) , 10.1002/IJC.29489
Li-Fan Lu, Georg Gasteiger, I-Shing Yu, Ashutosh Chaudhry, Jing-Ping Hsin, Yuheng Lu, Paula D. Bos, Ling-Li Lin, Carolyn L. Zawislak, Sunglim Cho, Joseph C. Sun, Christina S. Leslie, Shu-Wha Lin, Alexander Y. Rudensky, A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner Immunity. ,vol. 43, pp. 52- 64 ,(2015) , 10.1016/J.IMMUNI.2015.04.022
A. Diallo, C. Minet, C. Le Goff, G. Berhe, E. Albina, G. Libeau, T. Barrett, The threat of peste des petits ruminants: progress in vaccine development for disease control Vaccine. ,vol. 25, pp. 5591- 5597 ,(2007) , 10.1016/J.VACCINE.2007.02.013
Kara L. Norman, Peter Sarnow, Modulation of Hepatitis C Virus RNA Abundance and the Isoprenoid Biosynthesis Pathway by MicroRNA miR-122 Involves Distinct Mechanisms Journal of Virology. ,vol. 84, pp. 666- 670 ,(2010) , 10.1128/JVI.01156-09
Dalan Bailey, Ashley Banyard, Pradyot Dash, Aykut Ozkul, Tom Barrett, Full genome sequence of peste des petits ruminants virus, a member of the Morbillivirus genus Virus Research. ,vol. 110, pp. 119- 124 ,(2005) , 10.1016/J.VIRUSRES.2005.01.013
Yanni Chen, Junbo Chen, Hui Wang, Jingjing Shi, Kailang Wu, Shi Liu, Yingle Liu, Jianguo Wu, HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1 PLOS Pathogens. ,vol. 9, ,(2013) , 10.1371/JOURNAL.PPAT.1003248
Victor Ambros, The functions of animal microRNAs Nature. ,vol. 431, pp. 350- 355 ,(2004) , 10.1038/NATURE02871
Yuanpeng Zhang, Jiao Jing, Xinfeng Li, Jingman Wang, Xiuli Feng, Ruibing Cao, Puyan Chen, Integration analysis of miRNA and mRNA expression profiles in swine testis cells infected with Japanese encephalitis virus. Infection, Genetics and Evolution. ,vol. 32, pp. 342- 347 ,(2015) , 10.1016/J.MEEGID.2015.03.037
Carrie A. Batten, Ashley C. Banyard, Donald P. King, Mark R. Henstock, Lorraine Edwards, Anna Sanders, Hubert Buczkowski, Chris C.L. Oura, Tom Barrett, A real time RT-PCR assay for the specific detection of Peste des petits ruminants virus. Journal of Virological Methods. ,vol. 171, pp. 401- 404 ,(2011) , 10.1016/J.JVIROMET.2010.11.022