Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients.
作者： B. Pesce , L. Soto , F. Sabugo , P. Wurmann , M. Cuchacovich
DOI: 10.1111/CEI.12017
关键词:
摘要: A new paradigm has emerged relating the pathogenesis of rheumatoid arthritis (RA), focused on balance between T helper type 17 cells and regulatory (T(regs) ). In humans, both subpopulations depend transforming growth factor (TGF)-β for their induction, but in presence inflammatory cytokines, such as interleukin (IL)-6, generation Th17 is favoured. Tocilizumab a therapeutic antibody targeting IL-6 receptor (IL-6R), which demonstrated encouraging results RA. The aim this study was to evaluate effect tocilizumab Th1 cells, IL-17 interferon (IFN)-γ double secretors Th17/Th1 T(regs) RA patients. Eight patients received monthly 24 weeks blood samples were obtained every 8 cell populations by flow cytometry. frequency evaluated peripheral mononuclear (PBMCs) activated vitro with polyclonal stimulus. identified expression forkhead box protein 3 (FoxP3) CD25 direct staining PBMCs. Although no changes detected or percentages increased after therapy. addition, infrequent subpopulation showed significant increment tocilizumab-treated conclusion, able skew towards more protective status, may contribute clinical improvement observed
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