A controlled study of isolation and endogenous microbial suppression in acute myelocytic leukemia patients

摘要: A prospective study of infectious morbidity in patients with acute myelocytic leukemia receiving chemotherapy was undertaken to test the effects a reduction ambient and/or endogenous microorganisms. Patients were randomly allocated receive: (1) neither barrier isolation nor antimicrobial suppression; (2) suppression (gentamicin, vancomycin, and nystatin) conventional ward reverse isolation; (3) filtered air; or (4) isolation, air, suppression. The presence infection at time randomization significant factor (p < 0.02) accounting for an increased death rate. Individuals housed isolator who initially uninfected demonstrated decrease acquisition severe infections after 23 days, fewer respiratory throughout period. Pseudomonas decreased patients. Fewer fatalities from infection, but more hemorrhage, noted received An remission rate seen isolated not antibiotics gut flora (not statistically significant). Significant improvement leukemic survival by these environmental manipulations found.