Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism.

作者: William F. Bosron , Ting-Kai Li

DOI: 10.1002/HEP.1840060330

关键词:

摘要: It is now widely accepted that the various pharmacologic and addictive consequences of alcohol consumption are related to the tissue concentration of ethanol or its metabolic …

参考文章(74)
Yoshida A, Wang G, Impraim C, Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity. American Journal of Human Genetics. ,vol. 34, pp. 837- 841 ,(1982)
L. Lumeng, W. F. Bosron, T.-K. Li, Rate-Determining Factors for Ethanol Metabolism in Vivo during Fasting Alcohol and Aldehyde Metabolizing Systems-IV. ,vol. 132, pp. 489- 496 ,(1980) , 10.1007/978-1-4757-1419-7_50
M Fukui, S H Chen, G Stamatoyannopoulos, Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity. American Journal of Human Genetics. ,vol. 27, pp. 789- 796 ,(1975)
John HEMPEL, Rolf BUHLER, Rudolf KAISER, Barton HOLMQUIST, Czeslaw ZALENSKI, Jean-Pierre WARTBURG, Bert VALLEE, Hans JORNVALL, Human liver alcohol dehydrogenase FEBS Journal. ,vol. 145, pp. 437- 445 ,(1984) , 10.1111/J.1432-1033.1984.TB08573.X
K J Balak, R H Keith, M R Felder, Genetic and developmental regulation of mouse liver alcohol dehydrogenase. Journal of Biological Chemistry. ,vol. 257, pp. 15000- 15007 ,(1982) , 10.1016/S0021-9258(18)33383-0
A. Yoshida, C.C. Impraim, I.Y. Huang, Enzymatic and structural differences between usual and atypical human liver alcohol dehydrogenases. Journal of Biological Chemistry. ,vol. 256, pp. 12430- 12436 ,(1981) , 10.1016/S0021-9258(18)43291-7
John HEMPEL, Hedvig BAHR-LINDSTROM, Hans JORNVALL, Aldehyde dehydrogenase from human liver FEBS Journal. ,vol. 141, pp. 21- 35 ,(1984) , 10.1111/J.1432-1033.1984.TB08150.X
Agarwal Dp, Goedde Hw, Misawa S, Harada S, Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication. American Journal of Human Genetics. ,vol. 32, pp. 8- 15 ,(1980)
H.W. Goedde, D.P. Agarwal, S. Harada, Pharmacogenetics of alcohol sensitivity. Pharmacology, Biochemistry and Behavior. ,vol. 18, pp. 161- 166 ,(1983) , 10.1016/0091-3057(83)90165-X