Maternal Energetics and the Developmental Origins of Prostate Cancer in Offspring

摘要: In 2014, Prostate cancer was the most commonly diagnosed in men Western world, but few modifiable risk factors exist for this disease. Many studies have examined association between obesity and prostate incidence, producing conflicting results. However, maternal energetics during periconception gestation has barely been considered as a potential factor, despite fact that tissue patterning early development occur utero. Maternal diabetes dramatically affect health at time of pregnancy, rodent human demonstrate effects manifest variety noncommunicable conditions offspring, including initiation mammary tumors. Importantly, directly alter embryo germ cell, or oocyte. Obesity-exposed oocytes exhibit alterations size, gene expression, chromosome structure, metabolism, adult offspring present with defects hyperplastic tissues. We propose here alters epigenetic metabolic functions oocyte, which are passed to sensitizing them precancerous conditions. Such an utero environment could provide “first hit” should be when making dietary recommendations expectant mothers.