CIRCULATING TUMOR CELLS (CTC's): EARLY ASSESSMENT OF TIME TO PROGRESSION SURVIVAL AND RESPONSE TO THERAPY IN METASTATIC CANCER PATIENTS

摘要: A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response therapy patients with MBC based upon the presence number of CTC's. The Cell Spotter® System is used enumerate CTC's blood. system immunomagnetically concentrates epithelial cells, fluorescently labels cells identifies quantifies absolute detected peripheral blood tumor load is, part, a factor prediction therapy. mean survival depended threshold 5 per 7.5 ml Detection metastatic represents novel cancers, suggests biological role for blood, indicates that detection could be considered an appropriate surrogate marker prospective therapeutic clinical trials.