Glypican 3 has a higher sensitivity than alpha‐fetoprotein for testicular and ovarian yolk sac tumour: immunohistochemical investigation with analysis of histological growth patterns

作者: Debra L Zynger , John C McCallum , Chunyan Luan , Pauline M Chou , Ximing J Yang

DOI: 10.1111/J.1365-2559.2010.03553.X

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摘要: Zynger D L, McCallum J C, Luan Chou P M & Yang X (2010) Histopathology 56, 750–757 Glypican 3 has a higher sensitivity than alpha-fetoprotein for testicular and ovarian yolk sac tumour: immunohistochemical investigation with analysis of histological growth patterns Aims:  (GPC3) been reported to be overexpressed in tumour (YST), but the not compared α-fetoprotein (AFP). YST can form numerous patterns expression GPC3 these studied. The aim was address aspects. Methods results:  Sections from or were subjected immunohistochemistry using (n = 39) AFP (n = 24). Overall immunoreactivity each case specific semiquantitatively evaluated (0–3+) intensity reactivity scored (0–3). All cases expressed (1+, 5%; 2+, 8%; 3+, 87%) strong (2.9). majority (58%) often focal (0, 42%; 1+, 33%; 25%) low (1.0). Using GPC3, >75% microcystic (n = 38), macrocystic (n = 26), solid (n = 21), glandular-alveolar (n = 8), endodermal sinus (n = 7), polyvesicular vitelline (n = 5), enteric (n = 4) micropapillary (n = 2) displayed 2+ 3+ positivity. Conclusions:  display variety that confused other germ cell components. detects all tested detecting AFP.

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