Vitamin B Status in Patients with Chronic Fatigue Syndrome

摘要: Some patients with chronic fatigue syndrome say they benefit from taking vitamin supplements. We assessed functional status for the B vitamins pyridoxine, riboflavin and thiamine in 12 vitamin-untreated CFS 18 healthy controls matched age sex. Vitamin-dependent activities--aspartate aminotransferase (AST) glutathione reductase (GTR) riboflavin, transketolase (TK) thiamine--were measured erythrocyte haemolysates before after in-vitro addition of relevant vitamin. For all three enzymes basal activity (U/g Hb) was lower than controls: AST 2.84 (SD 0.62) vs 4.61 (1.43), P < 0.001; GTR 6.13 (1.89) 7.42 (1.25), 0.04; TK 0.50 (0.13) 0.60 (0.07), 0.04. This also true activated values: 4.91 (0.54) 7.89 (2.11), 8.29 (1.60) 10.0 (1.80), 0.56 (0.19) 0.66 (0.08), 0.07. The activation ratios, however, did not differ between groups. These data provide preliminary evidence reduced status, particularly patients.