Stressor exposure has prolonged effects on colonic microbial community structure in Citrobacter rodentium-challenged mice.

摘要: Stressor exposure significantly affects the colonic mucosa-associated microbiota, and exacerbates Citrobacter rodentium-induced inflammation, effects that can be attenuated with probiotic Lactobacillus reuteri. This study assessed structure of microbiota in mice exposed to a social stressor (called disruption), as well non-stressed control mice, during challenge pathogen C. rodentium. Mice were or home cage conditions for six consecutive days all challenged rodentium immediately following first stressor. In addition, received L. reuteri, vehicle control, via oral gavage each exposure. The stressor-exposed had significant differences microbial community composition compared mice. difference was evident six-cycle stressor, on Day 6 post-C. challenge, persisted up 19 after termination. different regardless whether they treated reuteri control. These data indicate rodentium, these are long-lasting not by