Differential effects of amphetamine and phencyclidine on the expression of growth-associated protein GAP-43.
作者： S. Vukosavic , S. Ruzdijic , R. Veskov , Lj. Rakic , S. Kanazir
DOI: 10.1016/S0168-0102(01)00222-X
关键词:
摘要: The purpose of the present study was to test changes in expression growth-associated protein (GAP-43) after chronic treatment with two different psychotomimetic drugs: amphetamine and phencyclidine. Rats were treated chronically for 7 days (twice daily) 5 mg/kg phencyclidine sacrificed 2, or treatment, following 7, 14 21 recovery full (7 days). Separate groups rats on same regiment haloperidol, control group vehicle. To determine effects drugs GAP-43 we have used Northern blotting quantitative situ hybridization. Treatment induced decrease mRNA expression, that detected also during period, up last day treatments. On contrary, PCP increase detectable from first until treatment. haloperidol did not produce significant expression. It can be suggested upregulation upon occurs as a result functional activation pathways able participate remodeling, while showed neurotoxic effect, decreasing mRNA.
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G. Stumm, J. Schlegel, T. Schäfer, C. Würz, H. D. Mennel, J.‐C. Krieg, H. Vedder, Amphetamines induce apoptosis and regulation of bcl‐x splice variants in neocortical neurons The FASEB Journal. ,vol. 13, pp. 1065- 1072 ,(1999) , 10.1096/FASEBJ.13.9.1065
LI Benowitz, NI Perrone-Bizzozero, SP Finklestein, ED Bird, Localization of the growth-associated phosphoprotein GAP-43 (B-50, F1) in the human cerebral cortex The Journal of Neuroscience. ,vol. 9, pp. 990- 995 ,(1989) , 10.1523/JNEUROSCI.09-03-00990.1989
D. Pohl, P. Bittigau, M. J. Ishimaru, D. Stadthaus, C. Hubner, J. W. Olney, L. Turski, C. Ikonomidou, N-Methyl-d-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 2508- 2513 ,(1999) , 10.1073/PNAS.96.5.2508
D. Burt, I Creese, S. Snyder, Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain Science. ,vol. 196, pp. 326- 328 ,(1977) , 10.1126/SCIENCE.847477
Kaj Blennow, Nenad Bogdanovic, Carl-Gerhard Gottfries, Pia Davidsson, The growth-associated protein GAP-43 is increased in the hippocampus and in the gyrus cinguli in schizophrenia Journal of Molecular Neuroscience. ,vol. 13, pp. 101- 109 ,(1999) , 10.1385/JMN:13:1-2:101
Selma Kanazir, Slobodanka Vukosavic, Ljubisav Rakic, Sabera Ruzdijic, Optimization of in situ hybidization histochemistry for localization of GAP-43 mRNA in fetal brain during human development Brain Research Protocols. ,vol. 1, pp. 280- 286 ,(1997) , 10.1016/S1385-299X(96)00040-2
L.M. Callahan, D.J. Selski, M.R. Martzen, J.E. Cheetham, P.D. Coleman, Preliminary evidence: decreased GAP-43 message in tangle-bearing neurons relative to adjacent tangle-free neurons in Alzheimer's disease parahippocampal gyrus. Neurobiology of Aging. ,vol. 15, pp. 381- 386 ,(1994) , 10.1016/0197-4580(94)90041-8
Peter M. Thompson, Angela C. Sower, Nora I. Perrone-Bizzozero, Altered levels of the synaptosomal associated protein SNAP-25 in schizophrenia Biological Psychiatry. ,vol. 43, pp. 239- 243 ,(1998) , 10.1016/S0006-3223(97)00204-7
Frank C. Barone, William J. Price, Palle Jakobsen, Malcolm J. Sheardown, Giora Feuerstein, Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischemia Pharmacology Biochemistry and Behavior. ,vol. 48, pp. 77- 85 ,(1994) , 10.1016/0091-3057(94)90501-0
Gary E Duncan, Brian B Sheitman, Jeffery A Lieberman, An integrated view of pathophysiological models of schizophrenia. Brain Research Reviews. ,vol. 29, pp. 250- 264 ,(1999) , 10.1016/S0165-0173(99)00002-8